CENTER FOR ADVANCED PRECLINICAL RESEARCH

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Part of: CENTER FOR ADVANCED PRECLINICAL RESEARCH

Location: Bucharest, Romania

The Center for Advanced Preclinical Research (CAPRes) at the USAMV Bucharest addresses both fundamental and applied research in the biomedical field. Located in the Faculty of Veterinary Medicine campus, the Center collaborates with the Veterinary Medicine Faculty’s Clinic, which has a modern Clinical Laboratory, which offers specialized services, such as health assessment and monitorization, anesthesia, surgical interventions and treatments, euthanasia and sample prelevation from experimental animals. The Center’s core facility, located in the Preclinical Sciences building, has an infrastructure suited for histological and immunochemical analysis, proteomics, transcriptomics, toxicology and pharmacodynamic studies. An important part of the laboratory’s activities is based on in vitro studies.
The research at CAPRes is directed toward the study and biological effects of advanced glycation end products (AGEs), and their involvement in human and animal pathologies and the development of biocompatible materials with potential biomedical applications.
The researchers at the CAPRes have expertise in obtaining, purifying and characterization of AGEs. Aside from the characterization of the biological impact of AGEs exposure, an important part of our portfolio is the characterization of biomaterial-cell/tissue interaction, used to assess biocompatibility and efficacy of such materials. Of major interest are the modulation of extracellular matrix, immune response and oxidative stress signaling pathways and biomarker levels by AGEs or biomaterials exposure.
Research focus
Engineer biomaterials for improved efficacy and biocompatibility for use in biomedical applications
Evaluate therapeutic efficacy of new drugs in animal models
Develop efficacious drug-biomaterial combination therapies
Discover and validate efficient biomarkers for the characterization of drug-biomaterials and target tissue dynamic systems
Generate hypothesis for clinical research

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Website: www.fmvb.ro